In today’s rapidly evolving understanding of the processes contributing to our health and well-being, it is becoming increasingly obvious that we have to take responsibility for our own health by adopting a holistic approach that addresses a broad spectrum of interconnected factors. However, even after years of biohacking, my experience is that finding a single location or provider that can offer comprehensive diagnostics and advice for our overall well-being is nigh impossible even in big cities. As a result, we often find ourselves navigating a complex landscape of specialized services, putting together the individual pieces of our longevity puzzle on our own.

A comprehensive evaluation of our well-being not only encompasses physical health, but also incorporates aspects such as lifestyle habits, and genetic predispositions. We need to focus more on preventive medicine and healthy longevity, identifying potential risks and implementing targeted interventions before issues escalate, rather than solely reacting to problems as they arise. I am continuously searching for places in the world that offer this synergistic view and enable us to live and age at our optimized healthy potential. And yet, I find that such places, while finally popping up on the map in the last few years, are still few and far between. I was therefore very happy to find that a new HealthyLongevity.clinic focused on longevity and healthy aging popped up near Prague and couldn’t wait to explore all the diagnostics and biohacking tools which they offer.

Location

The Healthy Longevity Clinic is located at an innovation hub in a small town at the edge of Prague, in the Czech Republic. It lies roughly 30 minutes car ride away from the center of Prague, and about 50 minutes away from the Prague airport. The location is a bit disconnected from everything else, but the car accessibility is good and Uber and Taxi coverage are reliable at any hour.

Offering and Service

Comprehensive Biochemical Examination

Let’s get the least special and the most common of the offered examinations out of the way first – full biochemical blood and urine exam. Being able to determine the current levels of all important vitamins and minerals in the body as well as metabolites from various processes, hormones, lipids, and complete blood count, gives you a foundation necessary for any other steps. While the test is relatively comprehensive (>80 biomarkers), you are likely able to get almost as broad a set of results from your local GP as well. However, having the information from this test along with some of the other more advanced diagnostic exams the clinic offers is where you start being able to connect dots a typical GP visit usually does not.

TL;DR – Diagnostic and Action Points

Diagnostic: Full biochemical blood and urine exam, including vitamins, minerals, metabolites, hormones, lipids, and complete blood count (>80 biomarkers). Identify deficiencies and toxicities.

Action points: Identify and address any deficiencies or imbalances, combine results with advanced diagnostic exams to form a more complete health picture, guide targeted interventions, adjust supplementation, consider IV infusions if needed, and collaborate with healthcare professionals to fine-tune personalized biohacking and longevity strategies.

Food Intolerances Determination

Food intolerances can be a significant factor in various health issues, ranging from bloating and fatigue to chronic inflammation and digestive discomfort. The clinic offers a comprehensive food intolerance examination that assesses your body’s response to 216 different food items. The test results give you an insight into your immune system’s potential reactions to certain foods, which may trigger inflammation and other symptoms.

For mild to moderate reactions, you may have to adjust your diet and pursue targeted supplementation to alleviate symptoms and reduce inflammation. In cases of severe reactions, complete avoidance of certain foods or compounds might be necessary for your health and well-being. By eliminating potential triggers and incorporating gut-friendly alternatives, you can work towards improved digestion, reduced inflammation, and enhanced overall wellness.

TL;DR – Diagnostic and Action Points

Diagnostic: Comprehensive food intolerance examination, assessing the body’s response to 216 different food items and potential immune system reactions.

Action points: Utilize test results to identify food triggers and adjust the diet accordingly, pursue targeted supplementation to alleviate symptoms and reduce inflammation, incorporate gut-friendly alternatives to promote improved digestion and overall wellness.

Genetic Testing

Comprehensive genetic analyses examine specific genes related to our health, such as the APOE gene, which influences our risk for Alzheimer’s disease, or the CYP1A2 gene, which affects caffeine metabolism. By understanding these genetic traits, we can make targeted lifestyle interventions to mitigate risks and optimize our well-being.

Lifestyle-focused genetic analyses are particularly intriguing, as they delve into our body’s metabolism of fats, sugars, proteins, and micronutrients. For instance, variations in the FTO gene can, among others, impact how we metabolize and store dietary fats, allowing us to tailor our diets accordingly.

Additionally, these kinds of genetic analyses reveal our muscle fiber types and their suitability for endurance or strength sports, enabling us to optimize our exercise routines for peak performance.

The clinic also explores genes from the perspective of their impact on micronutrient metabolism, microbiome health, and detoxification processes. Based on these analyses, personalized mixes of micronutrients and other substances essential for our body can be created. For example, individuals with a higher demand for antioxidants due to their genetic makeup might benefit from a tailored supplement containing a higher dose of vitamin C or selenium. Some laboratories (although I have not asked HLC about it) also offer mixes specifically designed for weight reduction, addressing individual factors such as insulin sensitivity or appetite regulation.

You may slowly be starting to see the synergies arise across the offered tests and this theme will continue. It makes a lot of sense to put together a biochemical exam based on your blood and note down various deficiencies. However, once you add on top of your personal genetic predispositions, you will be able to make more informed choices of how to address these deficiencies (e.g. which form of a micronutrient you are able to absorb, or which nutrient metabolism may be impaired in your organism to begin with thus resulting in deficiencies even with sufficient nutrition and supplementation).

TL;DR – Diagnostic and Action Points

Diagnostic: Comprehensive genetic analyses (e.g. APOE, CYP1A2, FTO), lifestyle-focused genetic tests, and examination of micronutrient metabolism, microbiome health, and detoxification processes.

Action points: Nutrigenomic-based dietary adjustments, epigenetic modulation (stress management, sleep optimization, targeted exercise routines), personalized supplementation based on genetic data and micronutrient metabolism, personalized exercise routines based on muscle fiber types.

Pharmacogenetics

As biohackers, understanding our unique genetic predispositions can help us optimize our health and well-being by tailoring our pharmaceutical interventions to our individual needs. Our genetic makeup can have a significant impact on how we metabolize, absorb, and respond to medications. Genetic variations can affect drug efficacy, dosage requirements, and the risk of experiencing side effects. By analyzing specific gene variants through pharmacogenetic testing, we can identify these differences and make more informed decisions about our medication regimens.

For instance, some individuals may carry a genetic variant that causes them to metabolize a specific drug more slowly, leading to higher blood concentrations and an increased risk of side effects. In such cases, a lower dosage may be required for optimal therapeutic effect. Conversely, individuals with gene variants causing rapid drug metabolism might need higher dosages to achieve the same benefits as those with normal metabolism.

TL;DR – Diagnostic and Action Points

Diagnostic: Pharmacogenetic testing to analyze specific gene variants affecting drug metabolism, absorption, and response.

Action points: Personalized medication regimens, dosage adjustments based on genetic makeup, minimizing side effects, optimizing therapeutic effects.

Epigenetic Testing

As an essential aspect of personalized health management, epigenetic testing offers a deeper understanding of our genetic blueprint’s dynamic nature. The examination carried out at HLC focuses on DNA methylation, a process that modulates the activation and inactivation of various regions of our DNA. The comprehensive epigenetic testing evaluates an individual’s biological age, the rate of aging within their body, and potential risks such as diabetes, immunosenescence (the “aging of the immune system”), and the predictive value of stem cell division rates – a critical factor in cancer prevention. By understanding these diagnostic markers, we can empower ourselves to take more targeted and effective preventive measures.

For instance, epigenetic testing may uncover a higher-than-normal methylation rate in a specific gene related to insulin sensitivity. This could indicate an increased risk of developing type 2 diabetes. Armed with this information, an individual can take proactive measures to reduce this risk, such as adopting a healthier diet, increasing physical activity, and closely monitoring blood glucose levels.

Another example may be identifying DNA methylation patterns associated with genes involved in stress response and neurotransmitter regulation, such as the serotonin transporter gene (SLC6A4) or the glucocorticoid receptor gene (NR3C1). This may signal a vulnerability to stress-related mental health issues and might inform lifestyle changes focused on mindfulness and building stress resistance.

TL;DR – Diagnostic and Action Points

Diagnostic: Epigenetic testing (DNA methylation) to assess biological age, rate of aging, diabetes risk, immunosenescence, and stem cell division rates.

Action points: Adopt personalized diet and exercise plans, practice stress reduction techniques (e.g., meditation, yoga), monitor blood glucose levels, consider supplements targeting specific epigenetic markers (e.g., resveratrol for sirtuin activation or folic acid for DNA methylation support), fasting protocols (affect expression levels of certain genes).

Telomere Attrition Testing

Telomere testing, also known as Telomere Attrition Testing (TAT), is a cutting-edge diagnostic tool that offers valuable insights into an individual’s aging process by measuring the length of their telomeres. Telomeres are the protective end-caps of our chromosomes, and their length serves as an indicator of cellular aging. With each cell division, telomeres shorten, and when they become too short, the cell can no longer divide, leading to cellular senescence or apoptosis.

The difference between an individual’s chronological age (measured in years since birth) and their biological age (determined by factors such as telomere length) can provide essential information about their overall health and the rate at which they are aging. Shorter telomeres correlate with accelerated aging and an increased risk of age-related diseases, while longer telomeres imply a more youthful biological age and potentially better health outcomes.

TL;DR – Diagnostic and Action Points

Diagnostic: Telomere Attrition Testing (TAT) to measure telomere length as an indicator of cellular aging.

Action points: Adopt a healthy lifestyle (balanced diet, regular exercise, stress management, and sufficient sleep) to support telomere health, consider supplements known to potentially support telomere length (e.g., antioxidants, omega-3 fatty acids, vitamin D, astragalus root extract, and resveratrol), and explore biohacks such as intermittent fasting or caloric restriction, which have been shown to support telomere length maintenance.

Mitochondria Analysis

Mitochondrial testing is a unique and specialized examination that offers valuable insights into the health and function of our cells’ powerhouses, the mitochondria. Mitochondria play a crucial role in cellular energy production, ensuring that our cells have the energy they need to perform their tasks efficiently. The mitochondrial genome and metabolism are often associated with the aging process, as natural aging typically results in a decline in cellular metabolism and reduced regenerative capacity of tissues. Alongside these changes, mitochondrial quality and activity also decrease.

Furthermore, mitochondrial DNA (mtDNA) mutations are frequently implicated in various age-related diseases. By enhancing the functionality of our mitochondria, we can potentially delay the onset of chronic and degenerative diseases associated with aging and slow down the aging process.

When it comes to mitochondrial health, there is a large number of biohacks that science suggests are beneficial, ranging from simply improving nutrition and (aerobic and strength) exercise to incorporating various hormetic stressors into your lifestyle, which trigger growth and optimization of mitochondria.

For example, one actionable intervention to improve mitochondrial health and function is to incorporate cold exposure into your routine. Cold exposure, such as taking cold showers or ice baths, has been shown to positively impact mitochondrial health by stimulating the production and activation of brown fat (which is densely occupied by mitochondria) and improving mitochondrial function in skeletal muscle.

Another, bit less trivial and more costly intervention may be hypoxic training, which involves exposing the body to low oxygen conditions, either by training at high altitude or using equipment that simulates altitude, such as altitude masks. Hypoxic training can improve mitochondrial function by stimulating the production of new mitochondria (mitochondrial biogenesis) and enhancing cellular adaptation to low oxygen levels.

TL;DR – Diagnostic and Action Points

Diagnostic: Mitochondrial testing to assess mitochondrial function, antioxidant capacity, and enzyme activity as indicators of cellular energy production and aging.

Action points: Improve nutrition and engage in aerobic and strength exercises, incorporate hormetic stressors for mitochondrial health (e.g., cold exposure, hypoxic training), consider supplements that support mitochondrial function (e.g., CoQ10, PQQ, alpha-lipoic acid, L-carnitine, and NAD+ precursors like NMN or NR), and monitor and address any identified mitochondrial dysfunction to potentially delay the onset of age-related diseases and slow down the aging process.

Gut Microbiome Testing

This examination investigates the bacterial diversity and composition of your gut microbiome, along with digestive functions, gut inflammation, permeability, and immune response.

Microbiome’s role in health

The gut microbiome plays a crucial role in various aspects of our health, including nutrient absorption, cravings, moods, and energy levels. Here’s a closer look at how the gut microbiome influences these aspects:

1. Nutrient absorption or malabsorption: The gut microbiome is vital for the breakdown and absorption of nutrients from the food we consume. Gut bacteria produce enzymes that help digest complex carbohydrates, proteins, and fats, making nutrients more accessible for absorption by our intestinal cells. Additionally, some gut bacteria synthesize essential vitamins and minerals, such as vitamins K and B. An imbalanced gut microbiome can lead to malabsorption, which may result in nutrient deficiencies, affecting overall health and well-being.
2. Cravings: The gut microbiome may possibly influence our food cravings through various mechanisms. Certain gut bacteria can release signaling molecules that affect our appetite and cravings. For example, some bacteria can produce short-chain fatty acids (SCFAs) that modulate the release of appetite-regulating hormones, such as ghrelin and leptin. Additionally, gut bacteria can communicate with our brain via the gut-brain axis, influencing our cravings and food choices.
3. Moods: The gut microbiome can impact our mood through the gut-brain axis, a complex communication network that connects the central nervous system with the enteric nervous system in the gastrointestinal tract. Gut bacteria can produce neurotransmitters, such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), which can influence mood and emotional regulation. Furthermore, gut bacteria can modulate inflammation and stress response, which can also affect mood and mental health.
4. Energy levels: The gut microbiome is involved in energy production and metabolism, as it plays a role in the breakdown of dietary components and the synthesis of essential molecules. The SCFAs produced by gut bacteria can serve as an energy source for cells in the body, particularly colonocytes (intestinal cells). Additionally, the gut microbiome can affect energy levels by regulating the absorption of nutrients and modulating hormones and signaling pathways involved in metabolism and energy homeostasis.

Microbiome optimization

Maintaining a healthy and balanced gut microbiome is therefore essential for optimizing all these processes. Tweaks and optimizations of the microbiome would then include the following steps:

1. Personalized nutrition: Tailoring the diet based on the results of your gut microbiome analysis and any identified food intolerances. Incorporating gut-friendly foods that promote a diverse and healthy microbiome, such as fermented foods (e.g., yogurt, kefir, sauerkraut, and kimchi), fiber-rich fruits and vegetables, and whole grains.
2. Targeted probiotics: Introducing specific probiotics to your regimen to help replenish and maintain beneficial gut bacteria populations. These beneficial bacteria can improve digestion, support the immune system, and contribute to better overall gut health.
3. Prebiotics: Including prebiotics in your diet to provide “fuel” for your gut bacteria. Prebiotics are found in foods such as bananas, asparagus, onions, and garlic. They help feed and support the growth of beneficial gut bacteria, contributing to a balanced and healthy gut microbiome.
4. Gut health supplements: Based on the results of the gut microbiome analysis, it may be an option to incorporate supplements designed to optimize and improve the gut environment. These may include digestive enzymes, anti-inflammatory agents, or other targeted supplements that address specific imbalances or issues within the gut.

TL;DR – Diagnostic and Action Points

Diagnostic: Gut microbiome diversity and composition, digestive functions, gut inflammation, permeability, immune response, food intolerances

Action points: Personalized nutrition, targeted probiotics, intestinal infusions, incorporate prebiotics, consider gut health supplements, optimize diet for microbiome balance, monitor and address nutrient deficiencies

Specialized Bloodwork – Omega Fatty Acids

Omega-3 and Omega-6 fatty acids play a crucial role in various bodily functions, including brain function, inflammation regulation, and cardiovascular health. However, the modern Western diet often results in an imbalance of these fatty acids, with an excessive intake of Omega-6s and an insufficient intake of Omega-3s. This imbalance can contribute to chronic inflammation, which is associated with a variety of health issues, such as cardiovascular disease, diabetes, and autoimmune disorders.

By conducting a blood test to measure the levels of Omega-3 and Omega-6 fatty acids, you can obtain a clear picture of your current fatty acid balance. This information can then be used to tailor your diet and supplementation plan to optimize your Omega-3 to Omega-6 ratio. For example, you may consider incorporating more Omega-3-rich foods, such as fatty fish, flaxseeds, and walnuts, or supplementing with a high-quality fish oil or algae-based supplement to increase your Omega-3 intake.

TL;DR – Diagnostic and Action Points

Diagnostic: Omega-3 & Omega-6 fatty acid levels, fatty acid balance, inflammation regulation.

Action points: Incorporate Omega-3 rich foods (fatty fish, flaxseeds, walnuts), supplement with high-quality fish oil or algae-based supplements, reduce Omega-6 rich foods (processed vegetable oils, fried foods), increase consumption of whole, unprocessed foods.

Specialized Bloodwork – NAD+

Measuring the levels of NAD+ (nicotinamide adenine dinucleotide) in the blood is a valuable diagnostic tool for understanding cellular health and energy metabolism. NAD+ is a vital coenzyme found in all living cells, playing a central role in energy production, DNA repair, and maintaining cellular communication. As we age, our natural levels of NAD+ decline, which can contribute to age-related health issues, fatigue, and a decrease in overall cellular function.

By testing your NAD+ levels through a blood test, you can gain insight into your cellular health and identify potential areas for improvement. Low NAD+ levels may indicate a need to address factors that could be contributing to this decline, such as poor diet, lack of sleep, or exposure to environmental toxins. To boost your NAD+ levels, you can take several approaches based on the results of your test:

1. Incorporate NAD+ precursors into your diet: Consuming foods rich in NAD+ precursors, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), can help increase your NAD+ levels. These precursors can be found in foods like edamame, broccoli, cabbage, cucumber, and avocado, or taken as supplements.
2. Engage in regular exercise: Physical activity has been shown to boost NAD+ levels and improve cellular function. Aim for a combination of both aerobic and resistance exercises to support overall health.
3. Prioritize sleep: Ensure you get enough high-quality sleep, as sleep deprivation has been linked to reduced NAD+ levels and impaired cellular function.
4. Reduce alcohol consumption: Excessive alcohol intake can deplete NAD+ levels. Cutting back on alcohol or abstaining altogether can help preserve your NAD+ stores.
5. Manage stress: Chronic stress can negatively impact NAD+ levels, so implementing stress reduction techniques such as meditation, deep breathing exercises, or yoga can support healthier NAD+ levels.
6. NAD+ infusion therapy: If your NAD+ levels are significantly low, you may want to explore NAD+ infusion therapy under the guidance of a qualified healthcare professional. This treatment involves the intravenous administration of NAD+, which bypasses the digestive system and delivers the coenzyme directly to your cells, providing a rapid and efficient boost in NAD+ levels. It is essential to consult with a healthcare professional before undergoing any medical treatment to ensure its safety and appropriateness for your individual health needs.

TL;DR – Diagnostic and Action Points

Diagnostic: Cellular health, energy metabolism, NAD+ levels.

Action points: Consume NAD+ precursor-rich foods or supplements (NR, NMN), engage in regular exercise (aerobic and resistance), prioritize high-quality sleep, reduce alcohol consumption, manage stress through meditation or yoga, consider NAD+ infusion therapy under the guidance of a healthcare professional, try intermittent fasting or time-restricted eating to enhance NAD+ production, experiment with cold exposure therapy to improve mitochondrial function and NAD+ levels.

Ultrasound & Atherosclerotic Score

Regular ultrasound examinations of blood vessels are a vital component of taking responsibility for one’s own health, although it is typically not necessary until a bit later age. The typical recommendation is to do these from the age of 45 onwards. By assessing the integrity and function of blood vessels, we can determine our atherosclerotic score, which quantifies the extent of narrowing within the blood vessels as a result of plaque buildup, thereby indicating the risk of developing conditions such as heart attack or stroke.

In addition to vascular health, abdominal ultrasound examinations allow us to evaluate the condition of many of our organs. For example, by examining the liver’s elasticity, which is an important indicator of liver fibrosis or cirrhosis, and identifying any morphological changes, we can detect early signs of liver disease or other underlying conditions. A healthy liver is more elastic and can effectively filter out toxins and process nutrients, whereas a less elastic liver may signify compromised function.

TL;DR – Diagnostic and Action Points

Diagnostic: Blood vessel integrity and function, atherosclerotic score, liver elasticity, morphological changes in the organs, kidney obstructions.

Action points: Monitor blood vessel health and atherosclerotic score, maintain a heart-healthy diet (low in saturated fats and high in fiber), engage in regular physical activity, manage blood pressure and cholesterol levels, avoid excessive alcohol consumption, maintain a healthy weight, consider supplementing with liver-supporting nutrients (e.g., milk thistle, N-acetylcysteine), cold exposure therapy (e.g., cold showers, ice baths, or cryotherapy) for inflammation reduction, red light therapy for improved circulation and tissue regeneration.

Allergy Testing using ALEX

Allergies can be a significant roadblock in achieving optimal well-being and performance, inflicting chronic inflammatory response on the body. One of the more advanced methods for diagnosing allergies is the ALEX (Allergy Explorer) method, an examination that measures IgE antibodies in your blood to detect and quantify your body’s sensitivity to specific allergens. With 117 allergen extracts and 178 molecular allergens available for testing, the ALEX method covers an impressively wide range of common allergens, such as pollens, molds, dust mites, animal dander, insect venom, and various foods.

With the data generated by this examination, we can fine-tune our environment, nutrition, and lifestyle choices to mitigate the impact of allergies on your body. For instance, by identifying specific food sensitivities, you can optimize your diet to reduce inflammation and promote overall health.

Moreover, the information obtained from the ALEX method may allow your doctor to develop targeted interventions such as immunotherapy, which can help reprogram your immune system to be more resilient against allergens.

TL;DR – Diagnostic and Action Points

Diagnostic: IgE antibody measurement, 117 allergen extracts, 178 molecular allergens, allergy detection

Action points: Fine-tune environment, nutrition, and lifestyle, Optimize diet to reduce inflammation, Discuss targeted interventions like immunotherapy with a doctor.

InBody and Plethysmograph Measurements

The InBody device is a sophisticated instrument that employs bioelectrical impedance analysis (BIA) to determine body composition accurately. By measuring resistance to a small electrical current as it passes through the body, the InBody device can quantify essential health parameters, including body fat percentage, lean muscle mass, and water distribution.

In conjunction with the InBody assessment, plethysmography is a non-invasive method used to evaluate blood vessel health and function. This technique measures changes in blood volume and flow in response to various stimuli, allowing for the assessment of blood vessel elasticity and stress resistance.

During a plethysmography examination, a specialized device is used to detect blood flow changes within the blood vessels. There are several types of plethysmography, including air, impedance, and photoplethysmography. While the specific methodology may vary depending on the type, the fundamental principle remains the same: by measuring alterations in blood volume, clinicians can gain insights into the elasticity and stress resistance of blood vessels.

For instance, in a typical photoplethysmography examination, a sensor is placed on the skin, often at the fingertip or earlobe. This sensor emits a light that penetrates the tissue and is absorbed by the blood. As blood volume and flow change, the amount of light absorbed also fluctuates, allowing the device to generate data on blood vessel function.

Throughout the examination, various stimuli, such as changes in body position or external pressure, may be introduced to assess the blood vessels’ ability to adapt and respond. By analyzing the data generated during the plethysmography examination, clinicians can identify potential vascular abnormalities and evaluate the overall health of the autonomic nervous system.

TL;DR – Diagnostic and Action Points

Diagnostic: Body composition (body fat percentage, lean muscle mass, water distribution), blood vessel elasticity, stress resistance of blood vessels, autonomic nervous system health

Action points: Adjust diet to optimize body composition, exercise to improve muscle mass and reduce body fat, promote hydration, engage in cardiovascular workouts to enhance blood vessel elasticity, Omega-3 and vitamin D supplementation, practice stress-reducing techniques (e.g., meditation, yoga) to support autonomic nervous system health, try cold exposure (e.g., cold showers, ice baths) for vascular health, use compression garments to improve circulation, explore neurofeedback training for autonomic nervous system regulation

VISIA Skin Analysis

Our skin, the largest organ in the human body, obviously shows signs of aging over time. Maintaining a youthful appearance might be the main marketed goal of skin-care, but to diminish skin’s function to only generating beauty would be naive and wrong. Regardless of our interest in outer appearance, keeping our skin healthy has many functional effects (synthesis of vitamin D, protection, detoxification, …) on our body. It deserves our attention.

The VISIA analysis system offers insights into key skin parameters, providing a comprehensive understanding of your skin’s quality. The system’s imaging module captures detailed images of your skin, enabling the measurement of both surface and subsurface changes. UV photography offers the most comprehensive data set available for evaluating and analyzing sun damage, including UV fluorescence imaging to detect porphyrins. The analysis can also assess the presence of spider veins, hyperpigmentation, inflammation, and other conditions in great detail. With the help of the TrueAge database, the skin’s biological age can be determined based on these factors.

Armed with the detailed analysis from the VISIA system, you can tailor interventions or treatments to address specific skin concerns. By monitoring changes over time, it is possible to track the effectiveness of these interventions and adjust them as needed to achieve and maintain more youthful and healthy skin.

TL;DR – Diagnostic and Action Points

Diagnostic: Key skin parameters, Skin quality, Surface and subsurface changes, UV damage, Porphyrins, Spider veins, Hyperpigmentation, Inflammation, Other skin conditions, Skin’s biological age

Action points: Topical retinoids, Collagen supplementation, Sun protection, Skincare antioxidants, Targeted laser treatments, Omega-3 and vitamin-rich diet, Stress management techniques, Sleep hygiene, Exercise routine, Red Light Therapy, Fasting regime

Magnetic Resonance Imaging

Full-body MRI

At its core, MRI technology employs a powerful magnetic field, radio waves, and a computer to generate detailed images of the body’s internal tissues and organs. The basic principle behind MRI involves the alignment of hydrogen atoms within the body when exposed to a strong magnetic field. When radio waves are applied, these atoms absorb the energy and then release it as they return to their original alignment. The released energy is detected by the MRI machine, and the data is converted into detailed images by a computer.

This technique allows us to see signs of disease or injury, thereby enabling timely interventions and fostering improved health outcomes. For instance, identifying cancerous growths in their nascent stages can dramatically enhance the effectiveness of treatments, resulting in more favorable prognoses. Furthermore, whole-body MRI can serve as a valuable tool in the management of chronic conditions and the monitoring of treatment progress, ensuring that any necessary adjustments are made in a timely fashion.

TL;DR – Diagnostic and Action Points

Diagnostic: Detailed images of internal tissues and organs, Early detection of diseases or injuries, Monitoring treatment progress

Action points: Implement timely interventions for detected issues, Enhance treatment effectiveness through early detection, Adjust treatment plans based on monitoring progress.

BrainKey MRI

A special chapter of MRI examinations is targeted brain MRI. The clinic offers diagnostics using the protocols given by BrainKey.ai, which images the brain, quantifies the sizes of its different functional areas, and compares them to the statistical averages of the population. The resulting model gives biohackers an insight into the functions of various areas of the brain and their statistical volume deviations.

These detailed images of the brain can be used to guide personalized, data-driven interventions aimed at optimizing cognitive performance and mental well-being. For example, a brain MRI might reveal that an individual has a lower than average volume in the hippocampus, a region critical for memory formation. In response, this individual might engage in targeted cognitive training exercises, such as memory-enhancing games or spatial navigation tasks, to stimulate neuroplasticity and potentially improve hippocampal function.

In addition to cognitive training, other lifestyle interventions may be informed by brain MRI findings. For instance, alterations in blood flow or brain metabolism might suggest the need for dietary adjustments, targeted supplementation, or other lifestyle changes to support optimal brain function. Moreover, we can track changes in brain volume over time and thus can gain insights into the natural progression of aging or the efficacy of targeted interventions designed to bolster brain health.

TL;DR – Diagnostic and Action Points

Diagnostic: Brain MRI (using BrainKey.ai protocols), functional area volume quantification, comparison to statistical population averages, evaluation of cognitive performance and mental well-being.

Action points: Targeted cognitive training exercises (e.g., memory-enhancing games, spatial navigation tasks), dietary adjustments (e.g., increase omega-3 intake, reduce refined sugar consumption), targeted supplementation (e.g., nootropics, phosphatidylserine), tracking changes in brain volume over time, assessing the efficacy of interventions for brain health, engaging in meditation or mindfulness practices, regular physical exercise for improved blood flow to the brain.

Spiroergometry Examination

A comprehensive spiroergometry test is an essential tool for biohackers seeking to optimize their physical fitness, functional capacity, and cardiovascular health during exercise. With the guidance of an expert in intensive care medicine, this examination uncovers vital insights, including VO2 max, aerobic threshold, lung capacity, and individual heart rate zones.

VO2 max, a measure of the maximum amount of oxygen your body can utilize during intense exercise, provides an indication of your aerobic endurance and overall fitness level. The aerobic threshold, on the other hand, is the point at which your body switches from primarily using aerobic metabolism to relying on anaerobic metabolism. By identifying your aerobic threshold, you can develop a training plan that maximizes aerobic efficiency, leading to improved endurance and performance.

Lung capacity is another critical aspect of the spiroergometry test. Assessing your lung capacity enables you to understand your respiratory system’s efficiency and identify any limitations or areas for improvement. A strong lung capacity supports effective oxygen delivery and carbon dioxide removal, contributing to overall cardiovascular health.

Additionally, the spiroergometry test provides valuable information about your individual heart rate zones. These zones, based on your heart rate at different intensities, enable you to tailor your training plan to achieve specific goals, such as increasing cardiovascular endurance, improving aerobic efficiency, or enhancing anaerobic capacity.

TL;DR – Diagnostic and Action Points

Diagnostic: VO2 max, Aerobic threshold, Lung capacity, Individual heart rate zones

Action points: Develop a training plan to maximize aerobic efficiency, Improve lung capacity through targeted breathing exercises, and Tailor workouts based on individual heart rate zones for specific fitness goals.

Conclusion

As mentioned in the introduction, any of these diagnostic tools, examinations, and subsequent interventions would require their own dedicated deep dive to do them justice. The amount of information and context is just too large. But even from this cursory glance, you may start to appreciate that having access to all of them in one place offers great convenience and synergies. Having healthcare professionals (or your own biohacker self) get access to all of this information and consider it holistically and in relation to one another can give you quite a superpower when it comes to optimizing and maintaining your health. I am fully convinced that clinics such as HLC are the future of medicine, even if that future is taking its sweet time to arrive and is currently just a dream in many parts of the world.

Sources

U.S. Department of Health and Human Services. (n.d.). Alzheimer’s disease genetics fact sheet. National Institute on Aging. Retrieved April 19, 2023, from https://www.nia.nih.gov/health/alzheimers-disease-genetics-fact-sheet

Marilyn C. Cornelis, B. S. (2006, March 8). Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. Retrieved April 19, 2023, from https://jamanetwork.com/journals/jama/fullarticle/202502

Robertson, S. (2022, December 29). Fat mass and obesity-associated gene (FTO). News. Retrieved April 21, 2023, from https://www.news-medical.net/health/Fat-Mass-and-Obesity-Associated-Gene-(FTO).aspx

Centers for Disease Control and Prevention. (2022, August 15). What is epigenetics? Centers for Disease Control and Prevention. Retrieved April 21, 2023, from https://www.cdc.gov/genomics/disease/epigenetics.htm

Najajreh, M. (2021, April 28). The impact of fasting on epigenetics. EpiQMAx. Retrieved April 20, 2023, from https://www.epiqmax.com/blog/article_280421-01

Zimmermann, A., Bauer, M., Kroemer, G., Madeo, F., & Carmona-Gutierrez, D. (2014). When less is more: Hormesis against stress and disease. Microbial Cell, 1(5), 150–153. https://doi.org/10.15698/mic2014.05.148

The microbiome. The Nutrition Source. (2022, July 25). Retrieved April 18, 2023, from https://www.hsph.harvard.edu/nutritionsource/microbiome/

LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013). Bacteria as vitamin suppliers to their host: A gut microbiota perspective. Current Opinion in Biotechnology, 24(2), 160–168.https://doi.org/10.1016/j.copbio.2012.08.005

Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020). The role of short-chain fatty acids from gut microbiota in gut-brain communication. Frontiers in Endocrinology, 11. https://doi.org/10.3389/fendo.2020.00025

Strandwitz, P. (2018). Neurotransmitter modulation by the gut microbiota. Brain Research, 1693, 128–133. https://doi.org/10.1016/j.brainres.2018.03.015

Omega fatty acids. Penn State Extension. (n.d.). Retrieved April 24, 2023, from https://extension.psu.edu/omega-fatty-acids

Simopoulos, A. P. (2002). The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, 56(8), 365–379. https://doi.org/10.1016/s0753-3322(02)00253-6

Strait, J. E. (2023, March 22). Scientists identify new fuel-delivery route for cells. Washington University School of Medicine in St. Louis. Retrieved April 24, 2023, from https://medicine.wustl.edu/news/scientists-identify-new-fuel-delivery-route-for-cells/

Wikimedia Foundation. (2023, March 12). Immunoglobulin E. Wikipedia. Retrieved April 24, 2023, from https://en.wikipedia.org/wiki/Immunoglobulin_E

Wikimedia Foundation. (2023, February 8). Bioelectrical impedance analysis. Wikipedia. Retrieved April 24, 2023, from https://en.wikipedia.org/wiki/Bioelectrical_impedance_analysis

Turn brain scans into actionable insights. BrainKey. (n.d.). Retrieved April 24, 2023, from https://www.brainkey.ai/tutorial

Fleissner, D. N., Schulze, D. V., & Dierkes, D. S. (2021, October 29). Performance diagnostics with spiroergometry: Cardiopraxis. Cardiopraxis®. Retrieved April 24, 2023, from https://www.cardiopraxis.de/en/leistungsdiagnostik-spiroergometrie/

Premium Longevity Clinic – first-class longevity. Premium Longevity Clinic – First-class longevity. (n.d.). Retrieved April 24, 2023, from https://www.healthylongevity.clinic/